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Search Results for " leukotriene receptor "

70

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1677L	Montelukast sodium MK0476,孟鲁司特钠	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Montelukast sodium (MK0476) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T16280	Nedocromil FPL 59002,尼多克罗	Leukotriene Receptor; Prostaglandin Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Nedocromil (FPL 59002) 对多种介质的作用或形成有抑制作用，包括组胺，前列腺素 D2和白三烯 C4。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T6893	MK-886 MK886,L 663536	Apoptosis; Leukotriene Receptor; COX; PPAR; FLAP	Apoptosis; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	MK-886 (L 663536)是一种细胞可渗透的，具有口服活性的 FLAP (IC50为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的IC50分别为 3 nM 和 1.1μM) 的抑制剂。它也是一种非竞争性PPARα拮抗剂，可以诱导细胞凋亡。
T26519	Ablukast Ro 23-3544,阿鲁司特	Leukotriene Receptor	GPCR/G Protein
	Ablukast (Ro 23-3544) 是白三烯受体的选择性拮抗剂，也是LTD4受体拮抗剂。可改善 LTC4 和抗原诱导的支气管狭窄。
T0694	Pranlukast 普鲁司特,ONO-1078,普仑司特	Leukotriene Receptor; IL Receptor; Others; TNF; NF-κB; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
	Pranlukast (ONO-1078) 是一种半胱氨酰白三烯受体 1 拮抗剂，可拮抗或减少支气管痉挛，用于哮喘研究。
T20615	Olsalazine 奥沙拉嗪,Dipentium,Salicylic acid	Others	Others
	Olsalazine (Dipentium) 是一种抗炎药，用于治疗炎症性肠病。它也是一种新型的 DNA 去甲基化剂。
T6736	Zafirlukast Vanticon,ICI 204219,Accolate,扎鲁司特	Leukotriene Receptor	GPCR/G Protein
	Zafirlukast (ICI 204219) 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T22358	Etalocib LY293111,VML295	Apoptosis; Leukotriene Receptor; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation
	Etalocib (LY293111) 是一种具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的 Ki 值为 25 nM。它还可诱导凋亡。它抑制 LTB4诱导的钙动员，lC50值为 20 nM。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T1677	Montelukast 孟鲁司特,Singular	Leukotriene Receptor; Lipoxygenase; LTR	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Montelukast (Singular) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T22787	FPL 55712	Others	Others
	Leukotriene receptor antagonist
T15002	CP-105696 Pfizer 105696	LTR	Immunology/Inflammation
	CP-105696 是一种具有强效性和选择性白三烯 B4 (LTB4) 受体拮抗剂，可用于研究异体移植物排斥反应。
T27979	Masilukast ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523	Leukotriene Receptor	GPCR/G Protein
	Masilukast(MCC-847) 是一种口服的白三烯D4 (LTD4) 受体拮抗剂，可用于研究与炎症相关的疾病。
T15647	Tipelukast MN 001,KCA 757	Leukotriene Receptor	GPCR/G Protein
	Tipelukast (KCA 757) 是一种新型可口服的白三烯受体 (leukotriene receptor) 拮抗剂，是具有抗炎活性，可减少纤维化，下调 TIMP-1、1 型胶原蛋白。Tipelukast 可用于研究哮喘疾病。
T16395	ONO4057 ONO-LB457	Leukotriene Receptor	GPCR/G Protein
	ONO4057 是一种具有有效性和口服活性的 Leukotriene B4 受体拮抗剂，其 IC50 值为 0.7±0.3 μM。 ONO4057 对大鼠同种异体移植的免疫抑制作用。
T68130	Pobilukast SKF 104353 Z2,SKF 104353	Leukotriene Receptor	GPCR/G Protein
	Pobilukast (SKF 104353) 是一种选择性半胱氨酰白三烯受体拮抗剂，可阻断磷脂酰肌醇代谢和白三烯D诱导的血栓素合成，可用于研究过度心肌再灌注损伤（MI/R）大鼠限制心肌损伤。
T68119	Ontazolast BIRM-270	LTR	Immunology/Inflammation
	Ontazolast 是一种小分子白三烯B4受体（LTB4R）拮抗剂，可用于治疗免疫系统疾病和呼吸系统疾病。Ontazolast 是治疗哮喘的候选化合物。
T28974	Ticolubant	Calcium Channel; LTR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ticolubant 是一种具有口服活性的白三烯 B4 拮抗剂，对人类中性粒细胞 LTB4 受体具有很高的亲和力（Ki = 0.78 nM），能阻断 LTB4 诱导的 Ca2+ 迁移，IC50 为 6.6±1.5 nM，并在小鼠皮肤炎症模型中显示出局部抗炎活性。
T68108L	Moxilubant HCl Moxilubant hcl(146978-48-5 Free base)	LTR	Immunology/Inflammation
	Moxilubant HCl 是一种小分子白三烯 B4 受体 1（LTB4R）拮抗剂，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究银屑病和类风湿关节炎。
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T27893	LY 203647 LY203647,LY-203647
	LY 203647 is a antagonist of leukotriene D4 and E4 receptor.
T27912	LY 290324 LY-290324,LY290324
	LY 290324 is an orally active, potent and selective antagonist of cysteinyl leukotriene (LTD4) receptor.
T22668	Cinalukast	Others	Others
	CysLT1 leukotriene receptor antagonist
T24304	L 648051 4-Apsob,L48051,L-648051
	L 648051 is a leukotriene D4 receptor antagonist.
T27896	LY 213024 LY-213024,LY213024
	LY 213024 is an antagonist of leukotriene B4 receptor.
T28699	SC-41930 CGS 24115,SC41930,CGS24115
	SC-41930 is a potent and selective antagonist of leukotriene B4 receptor.
T27916	LY 306669 LY-306669,LY306669
	LY 306669 is an antagonist of leukotriene B4 receptor.
T15803	LY223982 SKF107324,CGS23131	Others	Others
	LY223982 is an effective and specific inhibitor of the leukotriene B4 receptor (IC50: 13.2 nM). It also can against [3H]LTB4 binding to LTB4 receptor.
T28527	RG 14893
	RG 14893 is a antagonist of high-affinity leukotriene B4 receptor.
T27913	LY 292728 LY292728,LY-292728
	LY 292728 is a highly potent antagonist of leukotriene B4 receptor.
T71043	MDL-43291
	MDL-43291 is a leukotriene receptor antagonist.
T10873	CP-96486	Others	Others
	CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM).
T69278	FPL-55712
	FPL-55712 is a CysLT1 leukotriene receptor antagonist.
T15801	LY210073	Others	Others
	LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).
T26809	BIIL 260 BIIL260,BIIL-260
	BIIL 260 is a leukotriene B4 (BLT1) receptor antagonist with anti-inflammatory activity.
T70477	SC 53228
	SC 53228 is a specific leukotriene B4 receptor antagonist.
T30827	Cgp 33304 Cgp-33304,Cgp33304
	CGP 33304 is a dual leukotriene receptor antagonist and phospholipase A2 inhibitor. It prevents hypoxia secondary to bronchial constriction induced by leukotriene in a shocking state.
T68418	Furodysinin lactone
	Furodysinin lactone is an agonist of human leukotriene B4 receptor.
T68831	Furodysinin
	Furodysinin is an agonist of human leukotriene B4 receptor.
T68348	Montelukast methylstyrene
	Montelukast methylstyrene is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T11764	KP496	Others	Others
	KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor.
T71152	Montelukast bis-sulfide
	Montelukast bis-sulfide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T10872	CP-96021 hydrochloride	Others	Others
	CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM).
T21821	REV 5901
	REV 5901 是一种口服有效的白三烯受体 (leukotriene receptor) 竞争性拮抗剂，Ki 值为 0.7 μM。REV 5901 也是一种 5-脂氧合酶 (5-lipoxygenase) 抑制剂。REV 5901 可用于涉及白三烯释放的哮喘研究。
T73793	20-Carboxy-Leukotriene B4
	20-Carboxy-Leukotriene B4 (20-COOH LTB4) 是 Leukotriene B4 (LTB4) 的代谢物。20-Carboxy-Leukotriene B4 以高亲和力与 BLT1 受体结合。20-Carboxy-Leukotriene B4 抑制 LTB4 介导的中性粒细胞反应，迁移、脱粒、白三烯生物合成。
T68496	Montelukast cyclopropaneacetamide
	Montelukast cyclopropaneacetamide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T69501	Montelukast alcohol
	Montelukast alcohol is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T71369	Montelukast sulfoxide
	Montelukast sulfoxide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T68295	Montelukast methyl ketone
	Montelukast methyl ketone is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.

化合物

Montelukast sodium

Cat.No: T1677L

Synonym: MK0476,孟鲁司特钠

Target: Leukotriene Receptor, LTR

Cat.No: T16280

Synonym: FPL 59002,尼多克罗

Target: Leukotriene Receptor, Prostaglandin Receptor, Histamine Receptor

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T6893

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

Cat.No: T26519

Synonym: Ro 23-3544,阿鲁司特

Target: Leukotriene Receptor

Cat.No: T0694

Synonym: 普鲁司特,ONO-1078,普仑司特

Target: Leukotriene Receptor, IL Receptor, Others, TNF, NF-κB, LTR

Cat.No: T20615

Synonym: 奥沙拉嗪,Dipentium,Salicylic acid

Target: Others

Cat.No: T6736

Synonym: Vanticon,ICI 204219,Accolate,扎鲁司特

Target: Leukotriene Receptor

Cat.No: T22358

Synonym: LY293111,VML295

Target: Apoptosis, Leukotriene Receptor, LTR

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Cat.No: T1677

Synonym: 孟鲁司特,Singular

Target: Leukotriene Receptor, Lipoxygenase, LTR

Cat.No: T22787

Target: Others

Cat.No: T15002

Synonym: Pfizer 105696

Target: LTR

Cat.No: T27979

Synonym: ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523

Target: Leukotriene Receptor

Cat.No: T15647

Synonym: MN 001,KCA 757

Target: Leukotriene Receptor

Cat.No: T16395

Synonym: ONO-LB457

Target: Leukotriene Receptor

Cat.No: T68130

Synonym: SKF 104353 Z2,SKF 104353

Target: Leukotriene Receptor

Cat.No: T68119

Synonym: BIRM-270

Target: LTR

Cat.No: T28974

Target: Calcium Channel, LTR

Cat.No: T68108L

Synonym: Moxilubant hcl(146978-48-5 Free base)

Target: LTR

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Cat.No: T27893

Synonym: LY203647,LY-203647

Cat.No: T27912

Synonym: LY-290324,LY290324

Cat.No: T22668

Target: Others

Cat.No: T24304

Synonym: 4-Apsob,L48051,L-648051

Cat.No: T27896

Synonym: LY-213024,LY213024

Cat.No: T28699

Synonym: CGS 24115,SC41930,CGS24115

Cat.No: T27916

Synonym: LY-306669,LY306669

Cat.No: T15803

Synonym: SKF107324,CGS23131

Target: Others

Cat.No: T28527

Cat.No: T27913

Synonym: LY292728,LY-292728

Cat.No: T71043

Cat.No: T10873

Target: Others

Cat.No: T69278

Cat.No: T15801

Target: Others

Cat.No: T26809

Synonym: BIIL260,BIIL-260

Cat.No: T70477

Cat.No: T30827

Synonym: Cgp-33304,Cgp33304

Furodysinin lactone

Cat.No: T68418

Cat.No: T68831

Montelukast methylstyrene

Cat.No: T68348

Cat.No: T11764

Target: Others

Montelukast bis-sulfide

Cat.No: T71152

CP-96021 hydrochloride

Cat.No: T10872

Target: Others

Cat.No: T21821

20-Carboxy-Leukotriene B4

Cat.No: T73793

Montelukast cyclopropaneacetamide

Cat.No: T68496

Montelukast alcohol

Cat.No: T69501

Montelukast sulfoxide

Cat.No: T71369

Montelukast methyl ketone

Cat.No: T68295

Cat. No.	Product Name	Target	Signaling Pathways
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T5714	5-O-Demethylnobiletin 5-DEMETHYLNOBILETIN,去甲基川陈皮素	Leukotriene Receptor; Lipoxygenase	GPCR/G Protein; Metabolism
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) 是从黄芪中分离出的多甲氧基黄酮，具有抗炎活性，可通过直接抑制 5-LOX 发挥作用，IC50为 0.1 μM。
TN1182	11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸	Leukotriene Receptor; NF-κB; Lipoxygenase	GPCR/G Protein; Metabolism; NF-κB
	11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
T21504	γ-Linolenic Acid methyl ester Methyl gamma-linolenate,γ-亚麻酸甲酯	LTR	Immunology/Inflammation
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T37972	12-OxoETE
	12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.

天然产物

Cat.No: T7786

Target: DNA gyrase

5-O-Demethylnobiletin

Cat.No: T5714

Synonym: 5-DEMETHYLNOBILETIN,去甲基川陈皮素

Target: Leukotriene Receptor, Lipoxygenase

11-Keto-beta-boswellic acid

Cat.No: TN1182

Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

γ-Linolenic Acid methyl ester

Cat.No: T21504

Synonym: Methyl gamma-linolenate,γ-亚麻酸甲酯

Target: LTR

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Cat.No: T37972

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